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Tablets with material gradients fabricated by three-dimensional printing.

Deng Guang Yu1, Xiang Liang Yang, Wei Dong Huang

  • 1Institute of Materia Medica, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.

Journal of Pharmaceutical Sciences
|May 15, 2007
PubMed
Summary

Three-dimensional printing created complex tablets with drug-free barriers and material gradients for controlled zero-order release. This technology enables high-dosage tablets with tailored drug release profiles.

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Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Drug Delivery Systems

Background:

  • Achieving zero-order drug release is crucial for effective therapeutic outcomes.
  • Traditional tablet manufacturing methods have limitations in creating complex drug release profiles.
  • Three-dimensional printing (3DP) offers novel possibilities for fabricating advanced drug delivery systems.

Purpose of the Study:

  • To fabricate complex matrix tablets with zero-order drug release using 3D printing.
  • To investigate the effect of radial material gradients and drug-free barrier layers on drug release.
  • To evaluate the mechanical and pharmacotechnical properties of the 3D-printed tablets.

Main Methods:

  • Fabrication of matrix tablets using 3D printing with ethylcellulose gradients and acetaminophen.

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  • Incorporation of drug-free release-barrier layers on tablet bases.
  • Characterization using crushing strength, friability, and content uniformity tests.
  • Microscopic analysis (environmental scanning electron microscopy) and fluorescence tracing for structural visualization.
  • In vitro erosion and dissolution studies to determine drug release mechanisms and profiles.

    • Main Results:

    • Tablets exhibited acceptable mechanical and pharmacotechnical properties.
    • Ethylcellulose gradients and drug-free layers successfully controlled drug release.
    • A two-dimensional surface erosion mechanism led to linear release of 98% of the drug in 12 hours.
    • Other release-retardation materials (sodium lauryl sulfate, stearic acid, Eudragit RS-100) also demonstrated controlled release effects.

    Conclusions:

    • 3D printing is a viable technology for producing complex tablets with zero-order drug release.
    • Material gradients and barrier layers are effective strategies for controlling drug release kinetics.
    • 3DP enables the creation of high-dosage tablets with specialized designs for desired drug release characteristics.