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Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

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Patch testing for evaluating drug reactions due to systemic antibiotics.

Peter M H Cham¹, Erin M Warshaw

¹University of Minnesota, School of Medicine, Minneapolis, MN, USA.

Dermatitis : Contact, Atopic, Occupational, Drug

|May 15, 2007

Summary

Patch testing can help diagnose antibiotic-induced drug eruptions. This review examines its use for exanthematous drug eruptions from systemic antibiotics, highlighting diagnostic potential.

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

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Published on: August 30, 2018

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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

Dermatology
Allergy and Immunology
Pharmacology

Background:

Drug eruptions are common adverse drug reactions.
Patch testing is a diagnostic tool for delayed hypersensitivity reactions.
Widespread acceptance of patch testing for drug eruptions is limited in North America.

Purpose of the Study:

To review the utility of patch testing for diagnosing exanthematous drug eruptions.
To focus on drug eruptions caused by systemic antibiotics.
To assess the available English-language literature on this topic.

Main Methods:

A MEDLINE database search was conducted.
Inclusion criteria focused on patch testing for systemic antibiotic-induced drug eruptions.
Articles were reviewed for relevance and findings.

Main Results:

Evidence suggests patch testing can be valuable for identifying causative antibiotics in exanthematous drug eruptions.
Specific antibiotic classes and their association with positive patch tests were identified.
Further research is needed to standardize protocols and increase clinical adoption.

Conclusions:

Patch testing shows promise as an adjunctive diagnostic tool for antibiotic-induced exanthematous drug eruptions.
Increased awareness and standardized protocols could improve its clinical utility.
Further investigation is warranted to confirm its efficacy and safety.