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Related Experiment Videos

Carcinoid heart disease.

Alain M Bernheim1, Heidi M Connolly, Timothy J Hobday

  • 1Division of Cardiovascular Diseases, Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

Progress in Cardiovascular Diseases
|May 15, 2007
PubMed
Summary
This summary is machine-generated.

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Carcinoid heart disease (CHD) management is complex, requiring simultaneous treatment of systemic disease and cardiac involvement. Early diagnosis and valve replacement surgery in selected patients improve survival and symptoms.

Area of Science:

  • Cardiology
  • Oncology
  • Valvular Heart Disease

Background:

  • Carcinoid heart disease (CHD) is a rare valvular heart disease complication of carcinoid syndrome.
  • Managing CHD is complex due to concurrent systemic malignancy and cardiac involvement.
  • Improved carcinoid syndrome treatments increase survival, potentially unmasking or worsening CHD.

Purpose of the Study:

  • To review the current literature on carcinoid heart disease.
  • To discuss the biology, diagnosis, treatment, and prognosis of CHD.
  • To highlight the role of early diagnosis and surgical intervention.

Main Methods:

  • Literature review of carcinoid heart disease.
  • Analysis of diagnostic modalities for CHD.
  • Evaluation of treatment strategies, including cardiac surgery.

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Main Results:

  • Carcinoid heart disease significantly increases morbidity and mortality.
  • Cardiac surgery, specifically valve replacement, is the only effective treatment for severe CHD with controlled systemic disease.
  • Valve replacement offers symptom relief and contributes to improved survival in CHD patients.

Conclusions:

  • Early diagnosis and timely surgical intervention in selected patients are crucial for optimal outcomes in carcinoid heart disease.
  • Valve replacement surgery is a key intervention for managing severe CHD.
  • Multidisciplinary management is essential for patients with carcinoid syndrome and cardiac involvement.