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Related Experiment Videos

Prophylactic mastectomy.

Shaheen Zakaria1, Amy C Degnim

  • 1Department of Surgery, Mayo Clinic and Mayo Foundation, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.

The Surgical Clinics of North America
|May 15, 2007
PubMed
Summary
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Prophylactic mastectomy (PM) may be considered for high-risk women, including BRCA gene carriers, to reduce breast cancer risk. However, PM remains controversial due to a lack of randomized controlled trials on its benefits and harms.

Area of Science:

  • Oncology
  • Genetics
  • Preventive Medicine

Background:

  • Increased identification of high-risk women for breast cancer through genetic testing and risk stratification models.
  • Availability of various risk-reducing options: surveillance, chemoprevention, prophylactic salpingo-oophorectomy (PSO), and prophylactic mastectomy (PM).

Purpose of the Study:

  • To identify high-risk women who may benefit from prophylactic mastectomy (PM).
  • To summarize existing data on the efficacy of PM in breast cancer prevention.

Main Methods:

  • Review of current literature and data on prophylactic mastectomy.
  • Identification of patient populations most likely to benefit from PM.

Main Results:

  • BRCA gene carriers and women with a strong family history are primary candidates for PM.

Related Experiment Videos

  • Prophylactic mastectomy (PM) efficacy data is summarized, but randomized controlled trials are lacking.

    • Conclusions:

    • Prophylactic mastectomy (PM) is a consideration for select high-risk women.
    • The benefits and harms of PM require further investigation through rigorous clinical trials.