Percentage non-caeruloplasmin bound copper
Related Experiment Video
Updated: Jul 15, 2026

Positron Emission Tomography Using 64-Copper as a Tracer for the Study of Copper-Related Disorders
Published on: April 28, 2023
Patrick J Twomey1, Anthony S Wierzbicki, Ivan M House
1Department of Clinical Biochemistry, The Ipswich Hospital, Heath Road, Ipswich IP4 5PD, UK. patrick.twomey@ipswichhospital.nhs.uk
Objectives:
To compare percentage non-caeruloplasmin bound copper (%NCC) to generally accepted values.
Design And Methods:
Using data for 338 normal individual patients, we calculated the %NCC.
Results:
The %NCC ranged (median) from -59.75% to 51.98% (8.75%) respectively. The non-parametric reference interval was -23.44% to 22.99% with 43.8% of the %NCC values >10%.
Conclusions:
We found the %NCC to be higher than generally accepted. This may be due to uncertainty from precision, bias and specificity.

