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Related Experiment Videos

Menthol: a refreshing look at this ancient compound.

Tejesh Patel1, Yozo Ishiuji, Gil Yosipovitch

  • 1Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.

Journal of the American Academy of Dermatology
|May 15, 2007
PubMed
Summary
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Menthol, a plant-derived compound, provides cooling sensations by activating the TRPM8 receptor. This review details menthol

Area of Science:

  • Dermatology
  • Pharmacology
  • Molecular Biology

Background:

  • Menthol, a cyclic terpene alcohol, has historical medicinal uses.
  • It is widely incorporated into topical dermatologic formulations for antipruritic, antiseptic, analgesic, and cooling effects.

Purpose of the Study:

  • To review recent advancements in menthol's mechanism of action.
  • To provide an overview of menthol's dermatologic applications.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of studies investigating menthol's interaction with TRPM8 receptors.

Main Results:

  • Menthol's cooling sensation is mediated by the transient receptor potential melastatin 8 (TRPM8) receptor.

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  • The discovery of TRPM8 elucidates menthol's mechanism of action, previously not fully understood by many dermatologists.

    • Conclusions:

    • Understanding menthol's interaction with TRPM8 is crucial for its dermatologic applications.
    • Further research can optimize menthol-based therapies for various skin conditions.