Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Combination blue dye sentinel lymph node biopsy and axillary node sampling: the Edinburgh experience.

U Chetty1, P K Y Chin, P H S Soon

  • 1Edinburgh Breast Unit, Western General Hospital, Edinburgh EH4 2XU, UK. udi.chetty@luht.scot.nhs.uk

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
|May 15, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pooled long-term outcomes from two randomized trials of axillary node sampling with axillary radiotherapy versus axillary node clearance in patients with operable node-positive breast cancer.

The British journal of surgery·2016
Same author

Time dependence of biomarkers: non-proportional effects of immunohistochemical panels predicting relapse risk in early breast cancer.

British journal of cancer·2014
Same author

Radiotherapy or tamoxifen after conserving surgery for breast cancers of excellent prognosis: British Association of Surgical Oncology (BASO) II trial.

European journal of cancer (Oxford, England : 1990)·2013
Same author

The clinical effectiveness and cost-effectiveness of different surveillance mammography regimens after the treatment for primary breast cancer: systematic reviews registry database analyses and economic evaluation.

Health technology assessment (Winchester, England)·2011
Same author

A randomised controlled trial of post-operative radiotherapy following breast-conserving surgery in a minimum-risk population. Quality of life at 5 years in the PRIME trial.

Health technology assessment (Winchester, England)·2011
Same author

The problem of hemophilia in oral surgery.

Journal of oral surgery·2010

Combining sentinel node biopsy with axillary node sampling improves breast cancer staging accuracy. This technique enhances detection rates and reduces false negatives, addressing limitations of the standard sentinel node biopsy for early breast cancer.

Area of Science:

  • Oncology
  • Surgical Pathology
  • Breast Cancer Staging

Background:

  • Sentinel node biopsy (SNB) is standard for breast cancer staging but has limitations.
  • Inability to identify the sentinel node occurs in ~5% of cases, with false negatives in ~7%.
  • Tumor blockage of lymphatic channels is a suspected cause of SNB failure.

Purpose of the Study:

  • To evaluate a combined technique of SNB and axillary node sampling.
  • To improve the accuracy of breast cancer staging by overcoming SNB limitations.

Main Methods:

  • A single-center study involving 434 patients with early breast cancer.
  • The combined technique involved sentinel node biopsy using blue dye and four-node axillary sampling.

Main Results:

More Related Videos

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

Related Experiment Videos

Last Updated: Jul 15, 2026

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
07:51

The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy

Published on: June 1, 2019

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery
11:49

Single-port Non-liposuction Endoscopic Axillary Lymph Node Dissection in Breast Cancer Surgery

Published on: April 3, 2026

  • A blue sentinel node was identified in 91.7% of cases (394/434).
  • The false-negative rate was reduced to 2.4%.
  • In 13 patients with no identified sentinel node, positive nodes were found in the axillary sample.

Conclusions:

  • Axillary node sampling significantly enhances the accuracy of blue dye sentinel node biopsy.
  • Pathological findings suggest lymphatic channel blockage by cancer is a primary reason for false-negative SNB results.