Development of striatal fast-spiking GABAergic interneurons
Marie-Françoise Chesselet1, Joshua L Plotkin, Nanping Wu
1Departments of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1769, USA. Mchesselet@mednet.ucla.edu
Progress in Brain Research
|May 15, 2007
Summary
Fast-spiking GABAergic interneurons in rat striatum mature significantly between postnatal days 12-19. Their development is influenced by GABAergic and cholinergic systems, impacting striatal function.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Cellular Neuroscience
Background:
- Fast-spiking GABAergic interneurons are crucial for striatal function, modulating cortical input and inhibiting projection neurons.
- Understanding the developmental timeline of these interneurons is essential for comprehending striatal maturation.
Purpose of the Study:
- To investigate the developmental trajectory of fast-spiking GABAergic interneurons in the rat striatum.
- To determine the critical period for the maturation of these interneurons and their functional properties.
Main Methods:
- Review of recent laboratory findings on striatal neuron development.
- Analysis of molecular and functional maturation markers between postnatal days 12-19.
Main Results:
- Fast-spiking GABAergic interneurons exhibit increased cortical control at postnatal day 12.
- Significant maturation of these interneurons occurs between postnatal days 12-19.
- GABAergic and cholinergic mechanisms regulate their molecular development during this period.
Conclusions:
- Fast-spiking interneurons mature significantly during a specific postnatal window in rats.
- These interneurons are positioned to influence striatal function and development early on.
- Pharmacological agents may impact these neurons during a protracted developmental phase, warranting further research.
