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Related Experiment Videos

TH-7B pneumatically driven sac-type ventricular assist device and drive system.

S Nitta1, T Yambe, Y Katahira

  • 1Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.

The Science Reports of the Research Institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku
|July 1, 1991
PubMed
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The TH-7B ventricular assist device demonstrated satisfactory antithrombogenicity in chronic animal studies. Minimal thrombus formation suggests suitability for clinical applications.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Devices
  • Materials Science

Background:

  • Ventricular assist devices (VADs) are crucial for managing heart failure.
  • Improving the hemocompatibility and antithrombotic properties of VADs is essential for patient outcomes.
  • The TH-7B device represents a novel approach to VAD design and control.

Purpose of the Study:

  • To evaluate the antithrombogenicity of the TH-7B pneumatically driven sac-type ventricular assist device.
  • To assess the performance of the integrated automatic control system in chronic animal experiments.
  • To determine the suitability of Cardiothane and Cardiomat coatings for blood-contacting surfaces.

Main Methods:

  • Development and implementation of the TH-7B VAD and its drive system.

Related Experiment Videos

  • Chronic animal experiments were conducted using adult goats.
  • Blood-contacting surfaces were coated with Cardiothane or Cardiomat for evaluation.

    • Main Results:

    • One out of fifteen goats experienced sudden thrombus formation after 34 days.
    • No gross thrombus formation was observed, with only a thin circular thrombus noted at connector junctions.
    • The antithrombogenicity of the TH-7B system was deemed satisfactory.

    Conclusions:

    • The TH-7B ventricular assist device exhibits promising antithrombotic characteristics.
    • The materials and design of the TH-7B VAD appear suitable for clinical use.
    • Further investigation may support the broader application of this VAD technology.