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Related Experiment Videos

Development of the total artificial heart control system.

T Yambe1, S Nitta, Y Katahira

  • 1Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.

The Science Reports of the Research Institutes, Tohoku University. Ser. C, Medicine. Tohoku Daigaku
|July 1, 1991
PubMed
Summary

Researchers explored using sympathetic neurograms to predict cardiac output for total artificial heart (TAH) control. This study shows sympathetic tone can forecast cardiac output, aiding real-time TAH system automation.

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Area of Science:

  • Biomedical Engineering
  • Physiology
  • Cardiovascular Research

Background:

  • Real-time control of total artificial hearts (TAH) requires accurate prediction of cardiac output.
  • Sympathetic neurograms offer a potential, non-invasive method to monitor cardiovascular function.

Purpose of the Study:

  • To investigate the utility of sympathetic tone and hemodynamic parameters in predicting cardiac output.
  • To develop an equation for real-time cardiac output prediction using sympathetic neurogram data.

Main Methods:

  • Acute animal experiments were conducted on adult mongrel dogs.
  • Renal sympathetic nerve activity (RSNA) was used as a measure of sympathetic tone.
  • Moving averages of mean left atrial pressure and mean aortic pressure represented preload and afterload.

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  • Multiple linear regression analysis was applied to time-series data.

    • Main Results:

    • A significant correlation was found between predicted and measured cardiac output.
    • The developed equation demonstrated the capability to prospect cardiac output.

    Conclusions:

    • Sympathetic neurograms show potential for real-time TAH automatic control systems.
    • Integrating sympathetic tone into TAH control can improve system performance and patient outcomes.