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Related Experiment Video

Updated: Jul 15, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain (PPOP)
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Published on: January 27, 2010

Pain experience during chorionic villus sampling and amniocentesis: a preliminary study.

F Vandenbossche1, J Horovitz, F Guyon

  • 1Maternité B, Hôpital Pellegrin, Place Amélie-Raba-Léon, 33076 Bordeaux Cedex, France.

European Journal of Obstetrics, Gynecology, and Reproductive Biology
|May 15, 2007
PubMed
Summary

Transabdominal chorionic villus sampling (TA-CVS) using a 19-gauge needle is more painful than using a 20-gauge needle or amniocentesis. Lower gauge needles may reduce pain perception during fetal sampling procedures.

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Area of Science:

  • Maternal-fetal medicine
  • Pain perception research
  • Minimally invasive procedures

Background:

  • Fetal sampling procedures like amniocentesis (AC) and transabdominal chorionic villus sampling (TA-CVS) are common in prenatal care.
  • Understanding maternal pain perception during these procedures is crucial for patient comfort and informed consent.

Purpose of the Study:

  • To compare maternal pain perception during amniocentesis (AC) and transabdominal chorionic villus sampling (TA-CVS) using different needle gauges.
  • To identify factors influencing pain levels during fetal sampling procedures.

Main Methods:

  • Three hundred women were divided into three groups: AC (group 1), TA-CVS with a 19-gauge needle (group 2), and TA-CVS with a 20-gauge needle (group 3).
  • The Visual Analog Scale (VAS) measured expected pre-sampling pain and actual post-sampling pain.

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  • Single and multivariate analyses examined factors influencing VAS scores.

    • Main Results:

    • No significant difference in pre-sampling pain perception across the three groups.
    • TA-CVS with a 19-gauge needle (VAS 3.62) was significantly more painful than TA-CVS with a 20-gauge needle (VAS 2.49) and AC (VAS 2.68).
    • Nulliparous patients, those undergoing 19-gauge TA-CVS, and those with high pre-sampling pain scores reported higher post-procedure pain.

    Conclusions:

    • Transabdominal chorionic villus sampling with a 19-gauge needle is the most painful fetal sampling procedure.
    • The use of a 19-gauge needle in TA-CVS may be unnecessary, as acceptable results are achieved with a 20-gauge needle, potentially reducing patient discomfort.