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Related Concept Videos

Pulmonary Embolism I: Introduction01:29

Pulmonary Embolism I: Introduction

Pulmonary embolism (PE) occurs when a thrombus, fat or air embolus, amniotic fluid, or tumor tissue blocks one or more pulmonary arteries. These blockages originate in the venous system or the right side of the heart.EtiologyPE primarily arises from deep vein thrombosis (DVT) and other hypercoagulable states, such as inherited thrombophilias. Additional etiological factors include venous stasis, commonly seen in obesity, and endothelial injury from surgery and trauma. Less common causes include...
Pulmonary Embolism I: Introduction01:19

Pulmonary Embolism I: Introduction

A blood clot, or thrombus, is a semi-solid mass composed of fibrin, platelets, and red blood cells. When it forms within a vessel, it can obstruct blood flow, known as thrombosis. If part of the clot detaches, it becomes an embolus that can travel and block distant vessels. When this occurs in the pulmonary arteries, it causes a condition known as pulmonary embolism (PE).Origin and ImpactMost often, the embolus originates from a thrombus in the deep veins of the lower limbs, a condition called...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Pulmonary Embolism III: Nursing Management01:27

Pulmonary Embolism III: Nursing Management

A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...

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Related Experiment Video

Updated: Jul 15, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

[Massive pulmonary embolism, thrombus in transit, and right ventricular dysfunction].

Luis Efrén Santos Martínez1, Juan Eddy Uriona Villarroel, José Emilio Exaire Rodríguez

  • 1Departamento de Cardioneumologí,. Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano Núm. 1. Col. Sección XVI, Tlalpan 14080, DF México. sanlui@cardiologia.org.mx

Archivos De Cardiologia De Mexico
|May 16, 2007
PubMed
Summary

Massive pulmonary embolism (PE) can be fatal. This case study shows successful treatment of a massive PE with mechanical thrombectomy and thrombolysis, improving hemodynamic status and pulmonary circulation.

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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
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Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

Related Experiment Videos

Last Updated: Jul 15, 2026

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet
09:22

Chronic Thromboembolic Pulmonary Hypertension and Assessment of Right Ventricular Function in the Piglet

Published on: November 4, 2015

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension
07:41

Induction and Phenotyping of Acute Right Heart Failure in a Large Animal Model of Chronic Thromboembolic Pulmonary Hypertension

Published on: March 17, 2022

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Vascular Surgery

Background:

  • Massive pulmonary embolism (PE) carries high mortality, often due to thrombus in transit causing right ventricular strain and hemodynamic collapse.
  • Treatment options for massive PE include thrombolysis and surgical embolectomy, with varying degrees of invasiveness and efficacy.
  • Understanding the interplay between obstruction extent, baseline cardiopulmonary status, and right ventricular function is crucial for managing massive PE.

Observation:

  • A patient presented with massive pulmonary embolism, evidenced by transthoracic echocardiogram revealing right auricular thrombi, right ventricular dysfunction, and pulmonary hypertension.
  • Right heart catheterization and angiography confirmed significant pulmonary artery obstruction and confirmed right ventricular dysfunction.
  • Elevated troponin-I levels indicated right ventricular strain secondary to the massive pulmonary embolism.

Findings:

  • A combined approach of mechanical thrombectomy using a pigtail catheter and local thrombolysis with recombinant tissue plasminogen activator was employed.
  • Immediate hemodynamic improvement was observed post-intervention.
  • Follow-up angiography after 24 hours demonstrated significant improvement in pulmonary circulation and reduced pulmonary artery pressures.

Implications:

  • This case highlights the efficacy of mechanical thrombectomy combined with thrombolysis for massive pulmonary embolism.
  • The successful outcome suggests this combined approach can rapidly restore hemodynamic stability and improve pulmonary circulation.
  • This strategy may offer a valuable treatment option for selected patients with massive PE, potentially reducing mortality and morbidity.