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Updated: Jul 15, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
Published on: February 10, 2023
Pybox monolithic miniflow reactors for continuous asymmetric cyclopropanation reaction under conventional and
M I Burguete1, A Cornejo, E García-Verdugo
1Department of Inorganic and Organic Chemistry, A.U. for Advanced Organic Materials, University Jaume I/CSIC, E-12071 Castellón, Spain.
Abstract:
Supported catalysts having pybox chiral moieties were prepared as macroporous monolithic miniflow systems. These catalysts are based on styrene-divinylbenzene polymeric backbones having different compositions and pybox chiral moieties. Their corresponding ruthenium complexes were tested for the continuous flow cyclopropanation reaction between styrene and ethyldiazoacetate (EDA) under conventional conditions and in supercritical carbon dioxide (scCO2). Ru-Pybox monolithic miniflow reactors not only provided a highly efficient and robust heterogeneous chiral catalyst but also allowed us to develop more environmental reaction conditions without sacrificing the global efficiency of the process.
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