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Modeling fractal-like drug elimination kinetics using an interacting random-walk model
Rebeccah E Marsh1, Terence A Riauka
1Department of Physics, University of Alberta, Edmonton, Alberta, Canada T6G 2J1. rmarsh@ualberta.ca
Abstract:
We introduce an interacting random-walk model to describe the residence time of drug molecules undergoing a series of sojourn times in the body before being permanently eliminated under either homogeneous or heterogeneous conditions. We show that short-term correlations between drug molecules lead to Michaelis-Menten kinetics while long-term correlations lead to transient fractal-like kinetics. By combining both types of correlation, fractal-like Michaelis-Menten kinetics are achieved, and the simulations confirm previous analytical results.
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