Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Felty's syndrome in a Nigerian.

I I Onyewotu1, G C Onyemelukwe, J U Okpapi

  • 1Department of Medicine, Ahmadu Bello University Hospital, Zaria, Nigeria.

Tropical and Geographical Medicine
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of Seasonal Changes on Asthma Control in North-Western Nigeria.

West African journal of medicine·2024
Same author

Effect of Obesity on Resistin Concentrations in Normal, Pre-Obese and Obese Apparently Healthy Nigerian-Africans.

West African journal of medicine·2022
Same author

Assessment of respiratory symptoms and lung function among textile workers at Kano Textile Mills, Kano, Nigeria.

Nigerian journal of clinical practice·2012
Same author

RAST-specific IgE to egg and milk in Nigerian asthmatic patients.

African journal of medicine and medical sciences·2011
Same author

Abdominal tuberculosis in surgical practice in northern Nigeria.

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria·2011
Same author

Fleroxacin vs Ciprofloxacin in the Management of Typhoid Fever: A Randomised, Open, Comparative Study in Nigerian Patients.

Clinical drug investigation·2008

This case report details the first Nigerian patient with Felty's syndrome, a rare complication of rheumatoid arthritis. The patient presented with splenomegaly and leukopenia, alongside impaired staphylococcal killing by granulocytes.

Area of Science:

  • Rheumatology
  • Hematology
  • Immunology

Background:

  • Felty's syndrome is a rare triad of rheumatoid arthritis, splenomegaly, and neutropenia.
  • It typically occurs in long-standing, seropositive rheumatoid arthritis.
  • This condition is associated with specific autoantibodies and impaired neutrophil function.

Observation:

  • A 55-year-old Nigerian woman with a 10-year history of seropositive rheumatoid arthritis presented with splenomegaly and leukopenia.
  • Radiological examination showed no erosions, and subcutaneous nodules were absent.
  • The patient exhibited a positive granulocyte-specific anti-nuclear factor and cryoglobulins containing IgA and IgM.

Findings:

  • The patient's polymorph-nuclear granulocytes demonstrated impaired staphylococcal killing capacity.

Related Experiment Videos

  • Despite the presence of splenomegaly and leukopenia, the rheumatoid arthritis was not severely deforming.
  • Laboratory findings included positive anti-nuclear factor and specific cryoglobulins.

    • Implications:

    • This case expands the known geographical and clinical spectrum of Felty's syndrome.
    • It highlights the importance of considering Felty's syndrome in African patients with rheumatoid arthritis and cytopenias.
    • Further research may elucidate genetic or environmental factors influencing Felty's syndrome presentation in diverse populations.