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Interfacing 3D Engineered Neuronal Cultures to Micro-Electrode Arrays: An Innovative In Vitro Experimental Model
Published on: October 18, 2015
Diverse population-bursting modes of adapting spiking neurons
Guido Gigante1, Maurizio Mattia, Paolo Del Giudice
1Department of Technologies and Health, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
Abstract:
We study the dynamics of a noisy network of spiking neurons with spike-frequency adaptation (SFA), using a mean-field approach, in terms of a two-dimensional Fokker-Planck equation for the membrane potential of the neurons and the calcium concentration gating SFA. The long time scales of SFA allow us to use an adiabatic approximation and to describe the network as an effective nonlinear two-dimensional system. The phase diagram is computed for varying levels of SFA and synaptic coupling. Two different population-bursting regimes emerge, depending on the level of SFA in networks with noisy emission rate, due to the finite number of neurons.
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