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Related Concept Videos

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Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
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Published on: February 4, 2021

Ostwald ripening, chiral crystallization, and the common-ancestor effect.

Julyan H E Cartwright1, Oreste Piro, Idan Tuval

  • 1Laboratorio de Estudios Cristalográficos, CSIC, E-18100 Armilla, Granada, Spain.

Physical Review Letters
|May 16, 2007
PubMed
Summary

We developed a model for chiral autocatalysis, revealing Ostwald ripening as key to achieving homochirality. This process, via the common-ancestor effect, explains how one crystal lineage dominates from an unbiased start.

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Area of Science:

  • Chemistry
  • Chemical Physics
  • Crystallization

Background:

  • Chiral symmetry breaking is crucial in chemistry and biology.
  • Experimental results showing complete chiral symmetry breaking from unbiased mixtures were previously unexplained.

Purpose of the Study:

  • To introduce an agent-based model for advection-mediated chiral autocatalysis.
  • To explain how complete chiral symmetry breaking is achieved from initially unbiased seed crystals.

Main Methods:

  • Agent-based modeling was employed.
  • Dissolution-crystallization processes, specifically Ostwald ripening, were incorporated.
  • The model simulates advection-mediated chiral autocatalysis.

Main Results:

  • Ostwald ripening was identified as the key mechanism for chiral symmetry breaking.
  • The common-ancestor effect was demonstrated as the pathway to homochirality.
  • The model successfully explains previously puzzling experimental observations.

Conclusions:

  • Ostwald ripening is essential for achieving homochirality in chiral autocatalysis.
  • The common-ancestor effect, driven by Ostwald ripening, leads to the dominance of a single chiral lineage.
  • This model provides a theoretical framework for understanding experimental chiral symmetry breaking.