Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Atomic Force Microscopy

Atomic Force Microscopy

Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estimation of carbon footprint in nuclear medicine: illustration of a french department.

European journal of nuclear medicine and molecular imaging·2025

Same author

Administration of neoadjuvant chemotherapy for muscle-invasive bladder cancer in real life: Are urologists still too cautious?

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2021

Same author

[Enteral nutrition in malnourished patients with lung cancer].

Revue des maladies respiratoires·2020

Same author

Sexual dysfunction after elective laparoscopic or endovascular abdominal aortic aneurysm repair in men.

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2020

Same author

Secondary bladder exstrophy repair with a bilateral gracilis muscle flap in an adult female patient: Case report of an original procedure.

Annales de chirurgie plastique et esthetique·2018

Same author

[Comparison of operative and oncologic results between partial nephrectomy and radiofrequency ablation for treatment of renal tumors in patients older than 75].

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie·2017

Search research articles

Related Experiment Video

Updated: Jul 11, 2026

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

Probing persistence in DNA curvature properties with atomic force microscopy.

J Moukhtar¹, E Fontaine, C Faivre-Moskalenko

¹Laboratoires Joliot Curie (USR 3010) et de Physique (UMR 5672), Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.

Physical Review Letters

|May 16, 2007

Summary

Genomic DNA

Area of Science:

Biophysics
Molecular Biology
Genetics

Background:

The wormlike chain model describes DNA flexibility.
Genomic DNA exhibits intrinsic curvature disorder.
Long-range correlations (LRC) can influence DNA structure.

Purpose of the Study:

To extend the wormlike chain model to include LRC in DNA's intrinsic curvature.
To investigate the impact of LRC on DNA persistence length.
To differentiate between sequence-induced curvature and increased flexibility in human DNA.

Main Methods:

Developed a mean-field extension of the wormlike chain model.
Incorporated long-range correlations (LRC) into the model.
Utilized atomic force microscopy (AFM) imaging.

More Related Videos

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

Related Experiment Videos

Last Updated: Jul 11, 2026

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Stretching Short Sequences of DNA with Constant Force Axial Optical Tweezers

Published on: October 13, 2011

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy

Published on: June 27, 2013

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

Published on: January 31, 2019

Performed DNA simulations.

Compared viral and human DNA fragments.

Main Results:

Stronger LRC in DNA's intrinsic curvature correlates with decreased persistence length.
Human DNA fragments showed a reduced persistence length compared to viral DNA.
Simulations and AFM imaging supported the findings.

Conclusions:

The observed decrease in human DNA persistence length is primarily due to sequence-induced large-scale intrinsic curvature.
Increased DNA flexibility is a less likely explanation for the reduced persistence length.