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Updated: Jul 14, 2026
Isolation of Leukocytes from the Human Maternal-fetal Interface
Published on: May 21, 2015
Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies
Myriam Mondestin-Sorrentino1, John C Smulian, Anthony M Vintzileos
1Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology, Jersey Shore University Medical Center, Neptune, NJ, USA. mondesmy@umdnj.edu
Problem:
Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited.
Method Of Study:
This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova.
Results:
The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210-4100), 2460 (1047-4688), 3660 (1451-4748) (P < 0.0021); the median (range) IL-10 concentrations in cervical secretions were in pg/mL: 38.3 (6.8-227.9), 10.9 (0-263.3), 9.5 (0-35.6); the mean IL10/IL-8 x 100 (+/- standard deviation) concentrations were: 3.33 +/- 0.65, 1.47 +/- 0.41, 0.38 +/- 0.52 (P = 0.0035) during the first, second and third trimesters, respectively.
Conclusion:
The patterns of cervical IL-8 concentration is inversely related to gestational age, and the ratio of IL-10/IL-8 decreases with advancing gestation.
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