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Related Concept Videos

Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved in a...
The Extracellular Matrix01:42

The Extracellular Matrix

In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.Composition of the Extracellular MatrixThe extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse molecules.
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...

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A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
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[PPARs and cell-cell or cell-extracellular matrix interactions].

Hossam Murad1, Cathy Fiatte, Emilie Brunner

  • 1EA3446, Proliférateurs de Peroxysomes, Faculté des Sciences, Vandoeuvre-les-Nancy, France.

Medecine Sciences : M/S
|May 16, 2007
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Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors regulating lipid metabolism, muscle physiology, and adipogenesis. Emerging research reveals their crucial, yet under-explored, roles in cell-cell and cell-matrix interactions, opening new therapeutic avenues.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Endocrinology

Context:

  • Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with diverse physiological roles.
  • PPAR subtypes (PPARα, PPARβ/δ, PPARγ) regulate lipid metabolism, skeletal muscle function, adipogenesis, and placental development.
  • Their involvement in cell-cell and cell-matrix interactions is an emerging area of research.

Purpose:

  • To review the current understanding of PPARs' roles in cell-cell and cell-matrix interactions.
  • To highlight recent findings suggesting PPARs' direct or indirect involvement in these interactions.
  • To explore the therapeutic potential of PPAR activation in modulating these interactions.

Summary:

  • PPARs (PPARα, PPARβ/δ, PPARγ) are nuclear receptors involved in metabolism, muscle physiology, and development.
  • While known for these roles, their participation in cell-cell and cell-matrix interactions is less understood.
  • Recent studies indicate PPARs influence these interactions, suggesting therapeutic applications.

Impact:

  • Provides a comprehensive overview of PPARs' less-explored functions in cell adhesion and extracellular matrix dynamics.
  • Identifies potential therapeutic strategies targeting PPARs for conditions involving aberrant cell interactions.
  • Highlights the need for further research into the mechanisms linking PPARs to cell-cell and cell-matrix communication.