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Brachyspina syndrome in two Holstein calves
Stefania Testoni1, Alessia Diana, Emilio Olzi
1Department of Veterinary Clinical Sciences, School of Veterinary Medicine, University of Padua, Via dell'Università 16, I-35020 Legnaro (PD), Italy.
Veterinary Journal (London, England : 1997)
|May 16, 2007
Summary
Brachyspina syndrome, a rare lethal skeletal malformation, caused stillbirth in two Italian Holstein calves. This genetic condition resulted in shortened trunks, long legs, and multiple visceral defects.
Area of Science:
- Veterinary Genetics
- Developmental Biology
- Teratology
Background:
- Brachyspina syndrome is a rare, lethal skeletal malformation.
- Understanding its genetic basis is crucial for cattle breeding.
- This report details a novel case in Italian Holstein calves.
Observation:
- Two stillborn Italian Holstein calves presented with characteristic Brachyspina syndrome.
- Physical examination revealed shortened trunks and disproportionately long legs.
- Radiography identified vertebral column abnormalities and visceral malformations.
Findings:
- The affected calves exhibited severe skeletal defects, including cervical and thoracolumbar vertebral anomalies.
- Multiple organ systems were malformed, affecting the heart, kidneys, genital tract, and gastrointestinal system.
- Both calves shared the same sire, strongly suggesting an inherited etiology.
Implications:
- This case highlights the importance of genetic screening in Italian Holstein populations.
- Identifying the specific gene mutation could aid in preventing Brachyspina syndrome.
- Further research is needed to elucidate the inheritance pattern and molecular mechanisms.
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