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Related Experiment Videos

Performance standards for toric soft contact lenses.

Jacqueline Tan1, Eric Papas, Nicole Carnt

  • 1Institute for Eye Research, School of Optometry and Vision Science, The University of New South Wales, Sydney, New South Wales, Australia.

Optometry and Vision Science : Official Publication of the American Academy of Optometry
|May 16, 2007
PubMed
Summary

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Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Standardized clinical techniques simplify toric soft contact lens (TSCL) assessment. This study establishes performance benchmarks for TSCL designs, aiding in the evaluation of on-eye behavior and patient satisfaction.

Area of Science:

  • Ophthalmic optics
  • Biomaterials science
  • Clinical research

Background:

  • Toric soft contact lenses (TSCLs) correct astigmatism but their on-eye stability can vary.
  • Standardized methods are needed to objectively assess TSCL performance.
  • Understanding lens behavior is crucial for optimizing visual correction and patient comfort.

Purpose of the Study:

  • To develop standardized clinical techniques for evaluating toric soft contact lens (TSCL) on-eye behavior.
  • To establish performance benchmarks for various TSCL designs.
  • To define acceptable performance standards for key clinical variables.

Main Methods:

  • Four prism-ballast, two peri-ballast, and one dynamic stabilization TSCL designs were tested in 20 subjects each.
  • Assessments included subjective comfort, lens mislocation, and rotational recovery after induced misalignment.

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  • Key metrics: percentage of lenses within +/-10 degrees of target orientation and orientation variability.

    • Main Results:

    • Performance cut-offs were defined for excellent, acceptable, and poor outcomes across comfort, mislocation, and rotational recovery.
    • Specific thresholds were established for the percentage of lenses achieving target orientation and orientation variability.
    • Data partitioning allowed for the classification of lens designs based on these performance metrics.

    Conclusions:

    • Standardized techniques for evaluating TSCL clinical performance have been successfully established.
    • Guidelines for assessing TSCLs provide a framework for clinical evaluation.
    • Potential performance differences linked to TSCL design variations were identified.