Neuropsychological/-psychiatric deficits in immune-mediated neuropathies

Albeit common, neuropsychological/psychiatric deficits in patients with autoimmune-mediated neuropathies have not received much attention; however, they can impose a considerable clinical problem. Especially in intensive-care treated Guillain Barré syndrome (GBS) severe psychosis may occur which may go unrecognised due to the severity of the neurological motor deficits. Fatigue may result in a major restriction of quality of life long after the acute phase of GBS and is also a major debilitating factor in chronic inflammatory neuropathies. Symptomatic treatment remains largely empirical.