Related Experiment Video
Updated: Jul 14, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
Reversal of salicylate-induced euglycemic delirium with dextrose
Nick Kuzak1, Jeff R Brubacher, James R Kennedy
1Department of Emergency Medicine and Anesthesia, University of British Columbia, Vancouver, British Columbia, Canada. nickkuzak@hotmail.com
Abstract:
Salicylate poisoning inhibits Krebs cycle enzymes and uncouples oxidative phosphorylation. Under these circumstances, we hypothesize that CNS glucose supply is sometimes unable to keep up with demand resulting in hypoglycorrhacia and delirium even in the face of serum euglycemia. Supporting this conjecture, we report two euglycemic patients with salicylate-induced delirium who responded to boluses of concentrated dextrose with a prompt improvement in mental status.
Related Concept Videos
SBAR II: Application of SBAR
SBAR Report from a Nurse to a Health Care Provider
S: "Hello, Dr. Smith. This is Jane, RN, from the Med Surg unit. I am calling to tell you about Ms. White in Room 210, who is experiencing increased pain and redness at her incision site. Her recent...
Prevention of Further Absorption of Poison
Hyperosmolar Hyperglycemic State
Pharmaceutical Poisoning: Treatment Strategies
Anticholinesterase Agents: Poisoning and Treatment
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is slower than the...
Depolarizing Blockers: Pharmocokinetics
