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Related Concept Videos

Interphase00:54

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Interphase00:54

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Interphase00:56

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...
Interphase00:56

Interphase

The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases of the cell cycle (G1, S, and G2), and mitosis (M). During interphase, which takes up about 95 percent of the duration of the eukaryotic cell cycle, cells grow and replicate their DNA in preparation for mitosis.
Phases of Interphase
Following each period of mitosis and cytokinesis, eukaryotic cells enter interphase, during which they grow and replicate...

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Updated: Jul 9, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Why do cells cycle with a 24 hour period?

Samuel Bernard1, Hanspeter Herzel

  • 1Institute for Theoretical Biology, Humboldt University, Invalidenstr. 43, 10115 Berlin, Germany. s.bernard@biologie.hu-berlin.de

Genome Informatics. International Conference on Genome Informatics
|May 16, 2007
PubMed
Summary

The circadian clock influences cell division, with cells dividing near 24-hour cycles proliferating faster. This resonance may aid normal cell growth and inhibit tumor development.

Area of Science:

  • Cell Biology
  • Chronobiology
  • Computational Biology

Background:

  • Human cells typically divide every 24 hours, synchronizing with physiological processes.
  • The circadian clock regulates daily rhythms and directly influences the cell division cycle.
  • Current evidence does not confirm the circadian clock's ability to entrain cell cycle to a 24-hour period.

Purpose of the Study:

  • To investigate the relationship between circadian control and cell cycle timing.
  • To determine if circadian regulation impacts cell proliferation rates.
  • To explore the implications of cell division timing for normal growth and tumor suppression.

Main Methods:

  • Development and utilization of a computational model for the cell cycle.
  • Simulations of cell proliferation under circadian control with varying interdivision times.

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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

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Last Updated: Jul 9, 2026

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters
10:38

Monitoring Cell-autonomous Circadian Clock Rhythms of Gene Expression Using Luciferase Bioluminescence Reporters

Published on: September 27, 2012

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

  • Analysis of population growth rates based on cell cycle duration.

    • Main Results:

    • Cells under circadian control with interdivision times near multiples of 24 hours exhibit faster proliferation.
    • Impaired growth of cell populations with cell cycle times significantly deviating from 24-hour multiples.
    • A resonance effect was observed between circadian rhythms and cell cycle duration.

    Conclusions:

    • Circadian regulation can enhance cell proliferation when the cell cycle time is close to 24-hour multiples.
    • This resonance phenomenon may be crucial for efficient normal cell proliferation.
    • The findings suggest a potential role in the suppression of tumor growth.