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Updated: Jul 14, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
In search of new cures for tuberculosis
Marina Protopopova1, Elena Bogatcheva, Boris Nikonenko
1Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, MD 20850, USA. marinaprotopopova@sequella.com
Abstract:
The last 10 years have seen resurgent industry activity in discovery and development of new drugs for the treatment of tuberculosis (TB), a growing widespread and devastating (more than 2 million deaths annually) bacterial infection that is of increasing concern in developing and developed nations alike. This review describes drugs currently being evaluated in the clinic for treatment of uncomplicated and drug resistant pulmonary TB, and updates the literature on 5 new drugs that entered clinical trials in the last 4 years.
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