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Related Concept Videos

Recycling Endosomes and Transcytosis00:58

Recycling Endosomes and Transcytosis

The recycling endosome, also known as the endosomal recycling compartment (ERC), is a part of the slow-recycling process of the endocytic pathway. Molecules internalized through receptor-mediated endocytosis are either degraded in the lysosomes or are recycled to the plasma membrane through the fast- or slow-recycling route.
The recycling endosome is not a single organelle but an extensively tubulated network of recycling pathways. It functions in storing molecules or transporting them across...
The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
Maturation of Endosomes01:28

Maturation of Endosomes

The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
ER Retrieval Pathway01:45

ER Retrieval Pathway

In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...

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Related Experiment Video

Updated: Jul 14, 2026

The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking
08:51

The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking

Published on: February 12, 2022

Recycling endosomes in neuronal membrane traffic.

Michael R Schmidt1, Volker Haucke

  • 1Institute of Chemistry and Biochemistry, Department of Membrane Biochemistry, Freie Universität Berlin, Berlin, Germany.

Biology of the Cell
|May 17, 2007
PubMed
Summary

Recycling endosomes may provide membrane for neurite growth during neuronal differentiation. This study proposes a model for how these endosomes achieve polarized sorting of membrane proteins in developing neurons.

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Last Updated: Jul 14, 2026

The Microscopy-Based Assay to Study and Analyze the Recycling Endosomes using SNARE Trafficking
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Published on: February 12, 2022

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Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes
08:15

Quantification of Endosome and Lysosome Motilities in Cultured Neurons Using Fluorescent Probes

Published on: May 22, 2017

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • Neurons are polarized cells with distinct membrane domains for signaling.
  • Endosomes play crucial roles in sorting membrane cargo in various cell types, including neurons.
  • The origin of membrane for neurite extension and the mechanism of polarized protein sorting in neurons are not fully understood.

Purpose of the Study:

  • To provide an overview of endosome functions in different cell types.
  • To explore the role of recycling endosomes in neuronal differentiation.
  • To propose a speculative model for recycling endosome function in polarized membrane sorting during neuronal development.

Main Methods:

  • Literature review of endosome functions in fibroblasts, epithelial cells, and neurons.
  • Analysis of insights from non-neuronal cell types.
  • Integration of recent findings on recycling endosomes in synaptic plasticity.

Main Results:

  • Endosomes are critical for membrane cargo sorting in neurons.
  • Recycling endosomes are implicated in membrane remodeling during synaptic plasticity.
  • A speculative model for recycling endosome involvement in neuronal differentiation is presented.

Conclusions:

  • Recycling endosomes are hypothesized to supply membrane for neurite extension.
  • A model is proposed for how recycling endosomes contribute to polarized membrane protein sorting during neuronal differentiation.