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Dial-a-mutant: web-based knockout collections for model organisms.

Eric S Haag1

  • 1Department of Biology, University of Maryland, College Park, MD 20742, USA. ehaag@umd.edu

Biology of the Cell
|May 17, 2007
PubMed
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Non-vertebrate model organisms like Caenorhabditis elegans and Arabidopsis thaliana provide accessible genetic tools. Large collections of loss-of-function mutants are now available online, aiding gene function studies.

Area of Science:

  • Eukaryotic cell biology
  • Model organism research

Background:

  • Biomedically relevant research often involves complex organisms that are difficult or expensive to study.
  • Non-vertebrate model organisms present a practical and accessible alternative for genetic research.

Purpose of the Study:

  • To review accessible online resources for loss-of-function mutants in non-vertebrate model organisms.
  • To highlight tools that facilitate gene function studies in Caenorhabditis elegans and Arabidopsis thaliana.

Main Methods:

  • Identification and review of online databases and projects for Caenorhabditis elegans and Arabidopsis thaliana mutants.
  • Focus on resources like the C. elegans Knockout Consortium, C. elegans National Bioresource Project, NemaGENETAG, and T-DNA Express.

Main Results:

Related Experiment Videos

  • Large collections of loss-of-function mutants are available for C. elegans and Arabidopsis thaliana.
  • Online resources allow identification and request of mutant strains for a significant portion of genes in these organisms.

Conclusions:

  • Accessible mutant collections in non-vertebrate model organisms significantly enhance the ability of researchers, including non-specialists, to conduct in vivo gene function studies.
  • These resources democratize genetic research in key model species.