Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating chemokine levels and miscarriage.

Brian W Whitcomb1, Enrique F Schisterman, Mark A Klebanoff

  • 1Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, Bethesda, MD, USA.

American Journal of Epidemiology
|May 17, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

GLP-1 Receptor Agonists in Reproductive Medicine: A Narrative Review and Investigational Pilot Survey of Patient Perspectives in Academic Reproductive Endocrinology.

Reproductive sciences (Thousand Oaks, Calif.)·2026
Same author

A machine learning approach using semen parameters and sperm mitochondrial DNA copy number to predict couples' fecundity.

F&S reports·2025
Same author

Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss.

Human reproduction (Oxford, England)·2025
Same author

Sleep characteristics in association with risk of sporadic anovulation among eumenorrheic women.

Chronobiology international·2025
Same author

Inferential Statistics and Direct versus Inverse Problems.

American journal of epidemiology·2025
Same author

Systematic review of the impact of calcium channel blockers on sperm function.

Reproductive toxicology (Elmsford, N.Y.)·2025
Same journal

Design and procedures for the greenness, cognitive performance and vascular outcomes in the northern Manhattan study (NOMAS-greenness).

American journal of epidemiology·2026
Same journal

Correction to: Home dampness and molds and occurrence of respiratory tract infections in the first 27 years of life: the Espoo Cohort Study.

American journal of epidemiology·2026
Same journal

A SIMPLE AND POWERFUL TEST OF VACCINE WANING.

American journal of epidemiology·2026
Same journal

Association Between maternal body mass index, offspring growth and pubertal timing: results from a longitudinal birth cohort study.

American journal of epidemiology·2026
Same journal

Correction to: Developing a novel algorithm to identify incident and prevalent dementia in Medicare claims-the ARIC Study.

American journal of epidemiology·2026
Same journal

RE: advancing observational research on arts and health: theory-informed approaches using the RADIANCE framework.

American journal of epidemiology·2026
See all related articles

Chemokines may influence pregnancy outcomes. Elevated epithelial cell-derived neutrophil-activating peptide (ENA)-78 levels, particularly when detected over 35 days before pregnancy loss, may indicate an increased miscarriage risk.

Area of Science:

  • Reproductive Immunology
  • Biomarkers in Pregnancy

Background:

  • Chemokines are implicated in immune regulation and inflammation.
  • Their role in pregnancy and miscarriage risk is not fully understood.

Purpose of the Study:

  • To investigate the association between circulating chemokine levels and the risk of miscarriage.
  • To identify potential early biomarkers for pregnancy loss.

Main Methods:

  • Serum samples from women with miscarriage (n=439) and controls (n=373) were analyzed.
  • Multiplex assays measured levels of six chemokines, including interleukin 8 and ENA-78.
  • Conditional logistic regression modeled the relationship between chemokine levels and miscarriage risk.

Main Results:

Related Experiment Videos

  • Overall, no significant association was found between most chemokines and miscarriage risk.
  • Elevated epithelial cell-derived neutrophil-activating peptide (ENA)-78 levels showed an increased risk of miscarriage when samples were collected >35 days before outcome (aOR=1.25).

    • Conclusions:

    • While most chemokines were not linked to miscarriage, ENA-78 may serve as an early indicator of miscarriage risk.
    • Further research is warranted to confirm ENA-78's predictive value in early pregnancy loss.