Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hybridization of Atomic Orbitals I03:24

Hybridization of Atomic Orbitals I

66.0K
The mathematical expression known as the wave function, ψ, contains information about each orbital and the wavelike properties of electrons in an isolated atom. When atoms are bound together in a molecule, the wave functions combine to produce new mathematical descriptions that have different shapes. This process of combining the wave functions for atomic orbitals is called hybridization and is mathematically accomplished by the linear combination of atomic orbitals. The new orbitals that...
66.0K
Hybridization of Atomic Orbitals II03:35

Hybridization of Atomic Orbitals II

48.2K
sp3d and sp3d 2 Hybridization
48.2K
Hybrid Zones02:29

Hybrid Zones

21.8K
Hybrid zones are narrow regions where two closely related species interact, mate, and produce hybrids. Relative to either parent species, hybrids may possess distinct phenotypic or genetic differences that impact their survival and reproductive success. The genetic variances introduced by hybridization influence species diversity and speciation processes within the hybrid zone.
21.8K
Fast Fourier Transform01:10

Fast Fourier Transform

918
The Fast Fourier Transform (FFT) is a computational algorithm designed to compute the Discrete Fourier Transform (DFT) efficiently. By breaking down the calculations into smaller, manageable sections, the FFT significantly reduces the computational complexity involved. Direct computation of an N-point DFT requires N2 complex multiplications, whereas the FFT algorithm needs only (N/2)log⁡2N multiplications, offering a much faster performance.
The computational efficiency of the FFT becomes...
918
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

8.0K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
8.0K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.4K
No description available
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparing kinetic profiles of SV2A radiotracers [<sup>18</sup>F]SynVesT-1 and [<sup>18</sup>F]UCB-J using PET imaging in mice.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Accurate Reference Region Calculation in Mouse Brain [<sup>18</sup>F]fallypride Studies.

Molecular imaging and biology·2026
Same author

Imaging brain development in a KCNQ2-developmental and epileptic encephalopathy mouse model: identifying early biomarkers for functional and structural brain changes.

EBioMedicine·2026
Same author

SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026
Same author

Rodent biodistribution and dosimetry of the PET radioligands [<sup>18</sup>F]CHDI-385 and [<sup>18</sup>F]CHDI-386 targeting mutant huntingtin aggregates.

Nuclear medicine and biology·2026
Same author

Preclinical evaluation of [<sup>11</sup>C]CHDI-009R for quantification of mutant huntingtin aggregates.

Journal of molecular medicine (Berlin, Germany)·2025

Related Experiment Video

Updated: Jan 22, 2026

Measuring Photophysiology of Attached Stage of Colacium sp. by a Cuvette-Type Fast Repetition Rate Fluorometer
07:03

Measuring Photophysiology of Attached Stage of Colacium sp. by a Cuvette-Type Fast Repetition Rate Fluorometer

Published on: November 12, 2021

2.7K

Fast hybrid SPECT simulation including efficient septal penetration modelling (SP-PSF).

Steven Staelens1, Tim de Wit, Freek Beekman

  • 1Department of Nuclear Medicine, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands. Steven.Staelens@UGent.be

Physics in Medicine and Biology
|May 17, 2007
PubMed
Summary

This study enhances Monte Carlo simulations for Single Photon Emission Computed Tomography (SPECT) imaging. A new method significantly speeds up the simulation of septal penetrating photons, improving image reconstruction and data generation.

More Related Videos

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K
An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
09:32

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants

Published on: November 8, 2017

8.2K

Related Experiment Videos

Last Updated: Jan 22, 2026

Measuring Photophysiology of Attached Stage of Colacium sp. by a Cuvette-Type Fast Repetition Rate Fluorometer
07:03

Measuring Photophysiology of Attached Stage of Colacium sp. by a Cuvette-Type Fast Repetition Rate Fluorometer

Published on: November 12, 2021

2.7K
A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods
09:49

A Whole Body Dosimetry Protocol for Peptide-Receptor Radionuclide Therapy PRRT: 2D Planar Image and Hybrid 2D+3D SPECT/CT Image Methods

Published on: April 24, 2020

10.4K
An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants
09:32

An Array-based Comparative Genomic Hybridization Platform for Efficient Detection of Copy Number Variations in Fast Neutron-induced Medicago truncatula Mutants

Published on: November 8, 2017

8.2K

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Computational Physics

Background:

  • Single Photon Emission Computed Tomography (SPECT) images are often degraded by scattered photons and septal penetration.
  • Accurate modeling of photon transport is crucial for quantitative SPECT imaging and image reconstruction.

Purpose of the Study:

  • To extend a Monte Carlo software for SPECT simulations to include septal penetration (SP) effects efficiently.
  • To accelerate the simulation of SP photons without significant loss of accuracy for various isotopes and collimators.

Main Methods:

  • Developed a fast method for SP photon simulation using object attenuation and a scalable septal penetration point spread function (SP-PSF).
  • Combined coarse sampling, detector pixel grid interpolation, and thresholding of SP-PSF elements to accelerate simulation.
  • Integrated SP-PSF simulation into a Convolution-based Forced Detection (CFD) Monte Carlo simulator.

Main Results:

  • Achieved a four-orders-of-magnitude acceleration in SP simulation with minimal accuracy reduction.
  • Added only 10% computational overhead to the existing CFD-based Monte Carlo simulator.
  • Enabled SPECT simulations of patient-like distributions, including SP, in under 5 seconds per projection angle.

Conclusions:

  • The enhanced Monte Carlo simulator efficiently models both primary and septal penetrated photons in SPECT.
  • The simulator is suitable for 3D model-based reconstruction and as a fast dataset generator for image processing and observer studies.
  • This advancement facilitates more accurate and faster SPECT image analysis and development.