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Published on: August 17, 2022
[Hypocalcemic cardiomyopathy secondary to hypoparathyroidism after a thyroidectomy: report of one case]
José Lam1, Patricio Maragaño, Bárbara Lépez
1Servicio de Medicina, Hospital Regional de Talca, Talca, Chile. joslam@mixmail.com
Insights
Chronic hypoparathyroidism and hypocalcemia can lead to severe heart failure. Prompt calcium supplementation significantly improved cardiac function in a patient with post-thyroidectomy hypothyroidism.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Calcium is crucial for normal heart function.
- Chronic hypoparathyroidism and hypocalcemia can arise secondary to thyroidectomy.
- Levothyroxine supplementation is standard treatment for hypothyroidism.
Observation:
- A 37-year-old woman developed rapid congestive heart failure after starting levothyroxine for post-thyroidectomy hypothyroidism.
- The patient had a history of Graves' disease treated with thyroidectomy at age 18.
- She presented with severe left ventricular dysfunction, valve insufficiency, pulmonary hypertension, and pericardial effusion.
Findings:
- Echocardiography showed severe systolic and diastolic left ventricular dysfunction, mitral and tricuspid valve insufficiency, systolic pulmonary hypertension, left atrial enlargement, and pericardial effusion.
- Treatment with calcium supplementation, diuretics, captopril, and digoxin resulted in rapid clinical improvement.
- Persistent left ventricular dilatation and systolic dysfunction were noted at 18-month follow-up, though other echocardiographic findings improved.
Implications:
- This case highlights a potential link between calcium deficiency and severe cardiac dysfunction.
- Prompt diagnosis and management of hypocalcemia are critical in patients with cardiac symptoms.
- Calcium supplementation can be a vital component in treating heart failure associated with hypoparathyroidism.
Abstract:
Calcium plays a central role in ventricular function. We report a 37 year-old woman with chronic hypoparathyroidism and hypocalcemia secondary to a thyroidectomy performed when she was 18 years old, as treatment for a Graves Basedow's disease. She did not have previous cardiac symptoms and rapid progressive congestive heart failure developed after the beginning of levothyroxin supplementation for post operative hypothyroidism. Echocardiography revealed severe systolic and diastolic left ventricular dysfunction, mitral and tricuspid valve insufficiency, systolic pulmonary hypertension, left atrial enlargement and pericardial effusion. Calcium supplementation in addition to diuretics, captopril and digoxin were followed by rapid clinical improvement. Follow up until 18 months showed persistent left ventricular dilatation and systolic dysfunction, with improvement of all the other echocardiographic findings.
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