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Reversible renal failure following opioid administration.
S A Hill1, K Quinn, M P Shelly
1Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
Anaesthesia
|November 1, 1991
Summary
Intravenous papaveretum caused acute kidney injury in a surgical patient. Naloxone reversed the anuria, suggesting codeine in papaveretum may impair renal function.
Area of Science:
- Nephrology
- Pharmacology
- Anesthesiology
Background:
- Postoperative renal dysfunction is a significant clinical concern.
- Opioid analgesics are commonly used during and after surgical procedures.
Observation:
- A patient receiving intravenous papaveretum developed anuria and impaired renal function within 6 hours post-surgery.
- Mean arterial pressure remained stable during the observation period.
Findings:
- Naloxone administration led to a sustained improvement in urine output.
- The renal impairment was potentially linked to elevated plasma codeine levels from papaveretum.
Implications:
- This case highlights a potential nephrotoxic effect of papaveretum, possibly due to its codeine content.
- Naloxone may be a useful intervention for opioid-induced renal dysfunction.
- Further research is warranted to explore the relationship between papaveretum, codeine, and acute kidney injury.