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Updated: Jul 14, 2026

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation
12:09

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

Published on: February 28, 2019

CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR

Anne-Marie McNicol1, Gavin Bendle, Angelika Holler

  • 1Department of Immunology and Molecular Pathology, University College London, London, UK.

European Journal of Immunology
|May 17, 2007
PubMed
Summary

T-cell receptor (TCR) genes dictate CD8 dependence in cytotoxic T lymphocytes (CTLs). CD8beta-chain is crucial for CD8-dependent TCR function, highlighting differences between CD8alpha/beta and CD8alpha/alpha dimers.

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