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Related Experiment Videos

Reference ranges for fetal ventricular width: a non-normal approach.

L J Salomon1, J P Bernard, Y Ville

  • 1Service de Gynécologie-Obstétrique, Centre Hospitalier Intercommunal de Poissy-St Germain, Poissy, France. laurentsalomon@wanadoo.fr

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
|May 17, 2007
PubMed
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New fetal cerebral ventricular width charts using the LMS method provide more accurate reference values. A 10 mm cut-off identifies about 1% of fetuses, aligning better with actual measurements than traditional methods.

Area of Science:

  • Medical imaging
  • Fetal development
  • Biostatistics

Background:

  • Traditional fetal cerebral ventricular width measurements rely on parametric methods with fixed cut-offs.
  • These methods may not accurately reflect skewed data common in biological measurements.
  • Accurate reference ranges are crucial for fetal health monitoring.

Purpose of the Study:

  • To construct fetal cerebral ventricular width reference charts using a large dataset.
  • To employ the LMS method for better fitting skewed measurements across gestational ages.
  • To compare the LMS method's accuracy against traditional normal distribution assumptions.

Main Methods:

  • Prospective collection of 4769 fetal cerebral ventricular width measurements by a single operator.

Related Experiment Videos

  • Application of the LMS (Lambda-Mu-Sigma) method to model median, coefficient of variation, and skewness against gestational age.
  • Comparison of predicted proportions of measurements >= 10 mm using LMS versus normal approximation with binomial tests.
  • Assessment of gestational age, fetal gender, and presentation influences using robust regression.

    • Main Results:

    • The LMS method accurately modeled the skewness of ventricular width measurements throughout gestation.
    • The LMS method predicted 1% of measurements >= 10 mm, which closely matched the observed 0.88% (P=0.25).
    • Traditional normal approximation significantly underestimated this proportion (0.4% expected vs. 0.88% observed, P<0.0001).
    • Male fetuses showed significantly larger ventricular widths than females (P<0.0001).

    Conclusions:

    • The study presents novel reference values for fetal cerebral ventricular width utilizing the LMS method.
    • The LMS-derived 10 mm cut-off identifies approximately 1% of the population, offering improved accuracy.
    • This method provides a more reliable assessment of fetal ventricular width compared to previous approaches.