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Related Experiment Videos

Using genomics to study how chromatin influences gene expression.

Douglas R Higgs1, Douglas Vernimmen, Jim Hughes

  • 1MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom. doug.higgs@imm.ox.ac.uk

Annual Review of Genomics and Human Genetics
|May 18, 2007
PubMed
Summary
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Understanding DNA

Area of Science:

  • Genomics and Epigenetics
  • Molecular Biology
  • Developmental Biology

Background:

  • The post-genome era presents a challenge in understanding DNA's role in biological processes and cell fate.
  • Current research is shifting from single-gene studies to investigating large genomic domains, chromosomes, and the entire genome.

Purpose of the Study:

  • To investigate the conversion of DNA code into biological processes.
  • To determine the hierarchy and order of events in gene regulation during differentiation and development.

Main Methods:

  • Development of advanced technical tools for large-scale genomic investigation.
  • Parallel study of transcriptional and epigenetic programs.
  • Analysis of nuclear position, replication timing, chromatin structure, and DNA methylation.

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Main Results:

  • Enabling investigation of entire genomes and large chromosomal domains.
  • Facilitating parallel analysis of gene expression and epigenetic modifications.
  • Providing a framework to understand gene switching during development.

Conclusions:

  • New technical tools allow comprehensive genomic and epigenomic analysis.
  • Understanding gene regulation requires studying both transcriptional and epigenetic factors.
  • This approach is crucial for deciphering cell fate determination and developmental processes.