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Updated: Jul 14, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Traceless synthesis of 3-N-substituted-2-thioxoquinazoline-4-ones on a soluble polymeric support
Hongdan Peng1, Yanling Huang, Jianhong Yang
1Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Faculty of Chemistry and Chemical Engineering, Hubei University, Wuhan, Hubei, PR China.
Abstract:
The synthesis of 3-N-substituted-2-thioxoquinazoline-4-ones is described with a traceless linker strategy using poly(ethylene glycol) (PEG) as a soluble polymeric support. Staudinger-Aza-Wittig reaction of PEG-supported azide with Ph(3)P and CS(2) gave the corresponding PEG-supported phenyl isothiocyanate. Treatment of the phenyl isothiocyanate with different primary amines led, via intramolecular cyclization and simultaneous cleavage from PEG, to 2-thioxoquinazoline-4-ones with of moderate to excellent yields.
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