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Updated: Jul 14, 2026

Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Novel approaches to assessing renal function in cirrhotic liver disease
Andrew J Portal1, Mark Austin, Michael A Heneghan
1Institute of Liver Studies, King's College Hospital, London, UK.
Abstract:
Renal dysfunction is common in patients with end-stage liver disease. Etiological factors include conditions as diverse as acute tubular necrosis, immunoglobulin A nephropathy and hepatorenal syndrome. Current standard tests of renal function, such as measurement of serum urea and creatinine levels, are inaccurate as the synthesis of these markers is affected by the native liver pathology. This article reviews novel markers of renal function and their potential use in patients with liver disease.
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