Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A biodegradable vascularizing membrane: a feasibility study.

Anchal Kaushiva1, Vladimir M Turzhitsky, Marissa Darmoc

  • 1Biomedical Engineering Department, Northwestern University, 2145 Sheridan Road E310, Evanston, IL 60208, USA.

Acta Biomaterialia
|May 18, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healing cascades and infections in wounds monitored using a wearable sensor of gaseous flux.

bioRxiv : the preprint server for biology·2026
Same author

Simultaneous regeneration of skin and bone in full-thickness cranial composite defects.

bioRxiv : the preprint server for biology·2026
Same author

A Multilabel Single Molecule Localization Microscopy Protocol for Investigation of Chromatin in the Dense Nuclear Environment.

Journal of visualized experiments : JoVE·2026
Same author

One chromatin, many structures: From ensemble contact maps to single-cell 3D organization.

Biophysical journal·2026
Same author

Gene transcription and chromatin packing domains form a self- organizing system.

bioRxiv : the preprint server for biology·2026
Same author

Spectroscopic Super-resolution Imaging of DNA Molecules using Intrinsic Contrast.

Journal of visualized experiments : JoVE·2026
Same journal

Corrigendum to "Senescent endothelial cells' response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis" [Acta Biomaterialia 166 (2023) 266-277].

Acta biomaterialia·2026
Same journal

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Acta biomaterialia·2026
Same journal

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function.

Acta biomaterialia·2026
Same journal

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.

Acta biomaterialia·2026
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
See all related articles

Biodegradable membranes promote vascularization for regenerative medicine. Slower degrading membranes enhance blood vessel formation and reduce fibrous capsule thickness, crucial for in vivo biosensors and tissue engineering.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Vascular network formation is essential for regenerative medicine and in vivo biosensor applications.
  • Biodegradable porous membranes offer potential for inducing vascularization.

Purpose of the Study:

  • To investigate if biodegradable porous membranes can induce vascularized fibrous capsule formation.
  • To determine the effect of varying degradation kinetics on neovascularization.

Main Methods:

  • Fabrication of poly(l-lactic acid) (PLLA) and poly(dl-lactic-co-glycolic) acid) (PLGA) membranes with controlled pore size (60µm).
  • In vitro degradation assessment using scanning electron microscopy.
  • In vivo evaluation in rats, measuring vascular density, fibrous capsule thickness, and tissue perfusion (hemoglobin content) via 4D elastic light scattering.

Related Experiment Videos

Main Results:

  • Slow-degrading membranes (PLLA, PLGA 50:50) induced significantly greater neovascularization compared to fast-degrading membranes (PLGA 75:25).
  • Slower degradation correlated with a thinner fibrous capsule formation.
  • Initial macrophage infiltration and sustained pore structure of slow-degrading membranes may contribute to enhanced vascularization.

Conclusions:

  • Degradation kinetics of biodegradable membranes critically influence neovascularization.
  • Optimizing degradation rates can enhance vascularization and capsule formation for biomedical applications.
  • These findings support the use of tailored biodegradable membranes in regenerative medicine and biosensor development.