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[Post-vaccinal hemi-convulsion hemiplegia syndrome]
P Pladys1, M Roussey, A Dabadie
1Service de Pédiatrie et Génétique Médicale, CHRU Pontchaillou, Rennes.
Insights
A rare case of hemiseizure-hemiplegia syndrome occurred in an infant after a diphtheria, pertussis, and tetanus vaccine booster. The syndrome appears linked to post-vaccination fever, not direct vaccine toxicity.
Area of Science:
- Pediatric Neurology
- Vaccinology
- Clinical Case Study
Background:
- Diphtheria, pertussis, and tetanus (DPT) vaccines are crucial for infant immunization.
- Hemiseizure-hemiplegia syndrome is a rare neurological condition.
- Understanding vaccine side effects is vital for public health.
Observation:
- An 18-month-old infant experienced hemiseizure-hemiplegia syndrome post-DPT booster.
- Clinical, CT scan, and EEG data were monitored over 2.5 years.
- The infant's condition developed following a period of high fever.
Findings:
- The syndrome's onset correlated with post-immunization hyperthermia.
- No evidence of direct neurologic toxicity from the vaccine was found.
- Literature review supports fever as a potential trigger.
Implications:
- This case highlights a potential link between hyperthermia post-vaccination and hemiseizure-hemiplegia syndrome.
- It suggests careful monitoring for fever after immunization in infants.
- Further research may clarify the pathophysiology and preventive strategies.
Abstract:
An 18-month-old infant developed hemiseizure-hemiplegia syndrome following a booster dose of vaccine against diphtheria, pertussis, tetanus, and poliomyelitis. Clinical, CT scan, and electroencephalographic findings during the two-and-a-half-year follow-up are described. The timing of events and data from the literature suggest that hemiseizure-hemiplegia syndrome is related to post-immunization hyperthermia rather than to direct neurologic toxicity of the vaccine.