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Screening library evolution through automation of solution preparation.

U Schopfer1, F Höhn, M Hueber

  • 1Lead Finding Center, Novartis Institutes for BioMedical Research, Postfach, Basel, Switzerland. ulrich.schopfer@novartis.com

Journal of Biomolecular Screening
|May 18, 2007
PubMed
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Automating compound solution preparation ensures high-throughput screening library quality. This improves compound identity, concentration, and management, leading to better drug discovery outcomes.

Area of Science:

  • Drug discovery and development
  • Chemical biology
  • High-throughput screening

Background:

  • Compound library quality is crucial for high-throughput screening (HTS) success.
  • Manual solution preparation introduces variability and degradation.
  • Ensuring correct compound identity and concentration is vital.

Purpose of the Study:

  • To present an automation concept for compound solution preparation.
  • To establish a foundation for life cycle management of screening solutions.
  • To demonstrate continuous improvement of screening libraries through automation.

Main Methods:

  • Implementing complete automation for solution preparation.
  • Integrating quality and process control measures.

Related Experiment Videos

  • Developing innovative process optimizations for a high-performance system.

    • Main Results:

    • Achieved full industrialization of compound solution preparation.
    • Enabled robust quality and process control for screening solutions.
    • Laid the groundwork for effective life cycle management of screening libraries.

    Conclusions:

    • Automation of solution preparation is key to maintaining compound library integrity.
    • Continuous quality and process control drive improvements in screening performance.
    • Industrialized solution preparation enhances the reliability and efficiency of drug discovery pipelines.