Related Experiment Video
Updated: Jul 14, 2026
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Prostate and lymph node proton magnetic resonance (MR) spectroscopic imaging with external array coils at 3 T to
Stijn W T P J Heijmink1, Tom W J Scheenen, Jurgen J Fütterer
1Department of Radiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. s.heijmink@rad.umcn.nl
Abstract:
In a patient suspected of having recurrent prostate cancer after radiation therapy, we demonstrate the feasibility of noninvasive proton magnetic resonance spectroscopic (1H-MRS) imaging of the prostate and a lymph node at 3 T using a matrix of external surface coils. Written informed consent was obtained from the patient. With 1H-MRS imaging, high choline with low citrate signal was observed in the prostate, and in the lymph node a signal of choline-containing compounds was identified. The tissue level of the compounds in the enlarged lymph node was estimated to be 8.1 mmol/kg water. Subsequent histopathological analysis of systematic transrectal ultrasound-guided prostate biopsy and computed tomography-guided biopsy of the lymph node confirmed the presence of prostate cancer in both.
