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Updated: Jul 14, 2026
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Immunofluorescence to Monitor the Cellular Uptake of Human Lactoferrin and its Associated Antiviral Activity Against the Hepatitis C Virus
Published on: October 1, 2015
Lactoferrin in health and disease
Marian L Kruzel1, Jeffrey K Actor, Istvan Boldogh
1Department of Integrative Biology and Pharmacology, the University of Texas, Health Science Center at Houston, Texas 77030, USA. marian.l.kruzel@uth.tmc.edu
Postepy Higieny I Medycyny Doswiadczalnej (Online)
|May 18, 2007
Summary
Lactoferrin, an iron-binding glycoprotein, bridges innate and adaptive immunity by regulating cell responses. This review highlights lactoferrin's crucial role in immune homeostasis and therapeutic potential.
Area of Science:
- Immunology
- Biochemistry
- Cell Biology
Background:
- Lactoferrin is an iron-binding glycoprotein with immunomodulatory functions.
- It acts as a mediator between innate and adaptive immune responses.
- Lactoferrin influences target cell responses and T-helper cell polarization.
Purpose of the Study:
- To summarize recent findings on lactoferrin's role in immune homeostasis.
- To highlight lactoferrin's significance in regulating immune responses.
- To explore the therapeutic potential of lactoferrin.
Main Methods:
- Minireview of recent research presented at the Lactoferrin Minisymposium.
- Analysis of data on lactoferrin's involvement in immune regulation.
- Synthesis of information on lactoferrin's role in infectious assault, trauma, and injury.
Main Results:
- Lactoferrin plays a key role in maintaining immune homeostasis.
- It significantly influences the resolution or progression of immune responses.
- Lactoferrin exhibits "bookend" properties in controlling initial immune reactions.
Conclusions:
- Lactoferrin is a critical mediator in immune system regulation.
- Its "bookend" properties are vital for managing initial immune assaults.
- Findings support the development of novel therapeutic protocols involving lactoferrin.
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