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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Community-based incidence of acute renal failure
C-Y Hsu1, C E McCulloch, D Fan
1Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-0532, USA. hsuchi@medicine.ucsf.edu
Kidney International
|May 18, 2007
Summary
Acute renal failure (ARF) is increasingly common, affecting more men and the elderly. New methods using serum creatinine reveal higher incidence rates than previously thought.
Area of Science:
- Nephrology
- Public Health
- Epidemiology
Background:
- Limited data exists on the true incidence of acute renal failure (ARF) in the general population.
- Hospital-based studies are confounded by varying thresholds and hospitalization rates.
- Previous reliance on low-sensitivity diagnostic codes underestimated ARF incidence.
Purpose of the Study:
- To quantify the incidence of non-dialysis and dialysis-requiring ARF.
- To utilize serum creatinine changes for more accurate ARF case identification.
- To assess trends in ARF incidence within a large integrated healthcare system.
Main Methods:
- Analysis of electronic health records from Kaiser Permanente of Northern California (1996-2003).
- Identification of non-dialysis ARF using inpatient serum creatinine level changes.
- Identification of dialysis-requiring ARF through medical records.
Main Results:
- Incidence of non-dialysis ARF increased from 322.7 to 522.4 per 100,000 person-years.
- Incidence of dialysis-requiring ARF increased from 19.5 to 29.5 per 100,000 person-years.
- ARF was more prevalent in men and the elderly; older adults (≥80 years) received dialysis less frequently.
Conclusions:
- Serum creatinine measurements provide higher estimates of non-dialysis ARF incidence than prior methods.
- Both dialysis-requiring and non-dialysis ARF are becoming more common.
- The rising incidence of ARF highlights its significant public health importance.
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