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Updated: Jul 14, 2026
07:01
Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
Migraine and epilepsy: clinical and pathophysiological relations
R De Simone1, A Ranieri, E Marano
1Headache Centre, Neurological Sciences Department, University Federico II of Naples, Via Pansini 5, I-80131 Naples, Italy. rodesimo@unina.it
Summary
Migraine and epilepsy, both chronic neurological disorders, frequently co-occur. This paper explores their comorbidity, shared mechanisms, and the use of anti-epileptic drugs for migraine prevention.
Area of Science:
- Neurology
- Clinical Neuroscience
Background:
- Migraine and epilepsy are chronic neurological disorders characterized by recurrent attacks.
- These conditions exhibit partial clinical and therapeutic overlap and are frequently comorbid.
Purpose of the Study:
- To discuss the epidemiologic evidence of migraine and epilepsy comorbidity.
- To explore potential shared physiopathologic mechanisms between these two disorders.
- To examine the rationale for using anti-epileptic drugs in migraine prophylaxis.
Main Methods:
- Review of epidemiologic data on migraine-epilepsy comorbidity.
- Analysis of potential shared pathophysiological pathways.
- Examination of clinical evidence for anti-epileptic drug efficacy in migraine.
Main Results:
- Evidence suggests a significant comorbidity between migraine and epilepsy.
- Shared underlying mechanisms may contribute to the co-occurrence of these conditions.
- Anti-epileptic drugs show potential for migraine prophylaxis.
Conclusions:
- Migraine and epilepsy share common features and frequently occur together.
- Understanding shared mechanisms may lead to improved therapeutic strategies.
- Anti-epileptic drugs represent a viable option for migraine management.
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