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Published on: December 3, 2020
Retrospective analysis of artemisinin pharmacokinetics: application of a semiphysiological autoinduction model
1Sahlgrenska Academy at Göteborg University, Department of Pharmacology, Göteborg, Sweden.
Aims:
To describe the time-course of the autoinduction of artemisinin by applying a semi-physiological pharmacokinetic model.
Methods:
Plasma concentration-time data from six clinical studies involving oral administration of artemisinin to healthy subjects and malaria patients were included in the analysis. NONMEM was used to apply a semi-physiological model incorporating metabolizing enzymes and a pharmacokinetic model including a separate hepatic compartment.
Results:
The model described the data well. The hepatic extraction ratio increased from 0.74 at pre-induced conditions to 0.98 after autoinduction of metabolism.
Conclusions:
Our model successfully described the time-course of autoinduction of metabolism of artemisinin in subjects receiving oral artemisinin.
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