Related Experiment Video

Updated: Jul 14, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Café au lait macules and juvénile polyps

Theresa R Pacheco1, Lisa S Scatena, Edward J Hoffenberg

  • 1Department of Dermatology, University of Colorado at Denver and the Health Sciences Center, Aurora,Colorado, USA. theresa.pacheco@uchsc.edu

Pediatric Dermatology
|May 19, 2007
PubMed

Insights

Children with juvenile polyposis showed a higher prevalence of café-au-lait macules. This study highlights a potential link between gastrointestinal polyps and skin hyperpigmentation in pediatric patients.

Area of Science:

  • Pediatric Gastroenterology
  • Dermatology
  • Genetics

Background:

  • Gastrointestinal polyposis syndromes often present with extra-intestinal manifestations, including skin findings.
  • Limited data exists on cutaneous features associated with juvenile polyposis.

Purpose of the Study:

  • To determine the prevalence of cutaneous hyperpigmented lesions, specifically café-au-lait macules, in children with juvenile polyposis and their relatives.
  • To investigate potential associations between juvenile polyposis and specific dermatological markers.

Main Methods:

  • A case series involving children with various polyposis types (juvenile polyposis coli, sporadic juvenile polyps, familial adenomatous polyposis coli) and their first-degree relatives.
  • Comprehensive skin examinations were conducted on consenting participants.

Main Results:

  • 8 out of 14 patients (57.1%) had at least one café-au-lait macule, significantly higher than the general population.
  • 4 out of 14 patients (28.6%) had multiple café-au-lait macules, also significantly higher than the general population.
  • Two patients with juvenile polyposis coli also presented with lentigines.

Conclusions:

  • A high proportion of children with juvenile polyposis exhibit café-au-lait macules.
  • Further research is warranted to explore a potential common pathway between hamartomatous polyps and café-au-lait macules.

More Related Videos

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration10:14

Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration

Published on: May 26, 2023

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Jaundice01:25

Jaundice

Jaundice, or icterus, is the yellow discoloration of the skin, sclerae, and mucous membranes. It happens when plasma bilirubin levels rise above 2.5-3 mg/dL, leading to bilirubin deposition in tissue.Bilirubin is a byproduct of hemoglobin degradation. In macrophages, hemoglobin breaks down into globin and heme. Globin is converted into amino acids, while heme is turned into biliverdin by heme oxygenase, which is then reduced to unconjugated bilirubin by biliverdin reductase.Unconjugated...
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...