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Related Experiment Video

Updated: Jul 14, 2026

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Collection of Human Follicular Fluid, Follicle Somatic Cells, and Immature Oocytes from Individuals Undergoing In Vitro Fertilization

Published on: October 24, 2025

Towards a more physiological approach to IVF.

Geeta Nargund¹, René Frydman

¹Department of Obstetrics & Gynaecology, St George's Hospital Medical School, Cranmer Terrace, London, SW17 0RE, UK. geetanargund@googlemail.com

Reproductive Biomedicine Online

|May 19, 2007

Summary

The International Society for Mild Approaches in Assisted Reproduction (ISMAAR) promotes patient-friendly fertility treatments like natural cycle IVF. These milder methods, including gentle stimulation and in-vitro maturation, are poised to become the standard of care.

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Area of Science:

Reproductive Medicine
Assisted Reproduction Technology (ART)

Background:

Conventional IVF protocols often involve high drug doses, significant risks, and substantial costs.
There is a growing need for more physiological, patient-centered approaches in assisted reproduction.

Purpose of the Study:

To introduce the International Society for Mild Approaches in Assisted Reproduction (ISMAAR).
To advocate for and advance milder, safer, and more affordable fertility treatments.
To foster research and education in gentle stimulation and natural cycle IVF.

Main Methods:

Focus on natural cycle treatments, gentle stimulation protocols, and in-vitro maturation of oocytes.
Promoting international multi-center scientific research.
Conducting practical workshops and educational seminars for ART professionals.

Main Results:

Emerging research indicates that modified natural cycle/mild stimulation IVF with antagonists may supersede conventional down-regulated cycles.
ISMAAR aims to facilitate dialogue with stakeholders to promote accessible IVF globally.

Conclusions:

Mild approaches in assisted reproduction offer a more physiological, less invasive, and potentially more cost-effective alternative.
ISMAAR is dedicated to advancing research, training, and advocacy for improved patient care in fertility treatments.