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Updated: Jul 14, 2026

Establishment of an Embryo Implantation Model In Vitro
Published on: June 21, 2024
Establishment of the need for oestrogen during implantation in non-human primates
A Jagannadha Rao1, S G Ramachandra, V Ramesh
1Indian Institute of Science, Bangalore 560 012, India. ajrao@biochem.iisc.ernet.in
Abstract:
Deprivation of oestrogen during post-ovulatory mated cycles in proven fertile female bonnet monkeys by tamoxifen, aromatase inhibitor or oestrogen antiserum resulted in inhibition of pregnancy establishment in all three groups of animals. However, more than 85% of the animals became pregnant within three exposures to proven fertile males in the control group. These results suggest the requirement for oestrogen in pregnancy establishment in primates. Based on this conclusion, it is suggested that use of a suitable and potent anti-oestrogenic compound can be exploited as an alternative approach to contraception.
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