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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Reduced cortical surface area in multiple sclerosis

Daniel B Hier¹, Jun Wang

¹Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA. dhier@uic.edu

Neurological Research

|May 19, 2007

Abstract

Objective:

To assess utility of cortical surface area as a measure of disease progression in multiple sclerosis (MS).

Methods:

We measured two-dimensional flattened cortical surface area on high-resolution magnetic resonance imaging (MRI) scans obtained in 15 subjects with clinically definite MS and ten normal subjects.

Results And Discussion:

Single hemisphere cortical area was reduced in MS patients compared with controls (96,451 versus 71,710 mm(2)). We found no significant relationship of cortical surface area to disability or disease duration. T2 lesion load was negatively correlated with two-dimensional cortical surface area (r=-0.62).

Conclusion:

Cortical surface area is decreased in MS and may be a useful measure of disease progression.

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Multiple Sclerosis l: Introduction

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