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Reduced cortical surface area in multiple sclerosis.

Daniel B Hier1, Jun Wang

  • 1Department of Neurology and Rehabilitation, University of Illinois at Chicago, Chicago, IL 60612, USA. dhier@uic.edu

Neurological Research
|May 19, 2007
PubMed
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Cortical surface area is reduced in multiple sclerosis (MS) patients compared to healthy individuals. This measure may help track disease progression, despite no direct link to disability or duration found.

Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Research

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • Accurate measures for tracking MS progression are crucial for patient management.
  • Cortical atrophy is a known feature of MS, but its utility as a quantitative marker needs further validation.

Purpose of the Study:

  • To evaluate the effectiveness of cortical surface area as a biomarker for disease progression in multiple sclerosis.
  • To compare cortical surface area between MS patients and healthy controls.

Main Methods:

  • High-resolution magnetic resonance imaging (MRI) was used to acquire brain scans.
  • Two-dimensional flattened cortical surface area was measured in 15 MS patients and 10 healthy controls.

Related Experiment Videos

  • Correlation analyses were performed to assess relationships between cortical surface area, disability, disease duration, and T2 lesion load.

    • Main Results:

    • Cortical surface area was significantly reduced in MS patients (71,710 mm²) compared to controls (96,451 mm²).
    • No significant correlation was found between cortical surface area and patient disability or disease duration.
    • A negative correlation (r=-0.62) was observed between T2 lesion load and cortical surface area, indicating greater lesion burden is associated with reduced cortical area.

    Conclusions:

    • Cortical surface area is decreased in individuals with multiple sclerosis.
    • Cortical surface area shows potential as a valuable quantitative measure for monitoring MS disease progression.
    • The association between T2 lesion load and reduced cortical area suggests a link between inflammatory activity and cortical atrophy in MS.