Possible recombination and gene adaptation exchanges among clinical echovirus strains: crossing the temporal and topological barriers
Related Experiment Video
Updated: Jul 14, 2026

Engineering and Evolution of Synthetic Adeno-Associated Virus (AAV) Gene Therapy Vectors via DNA Family Shuffling
Published on: April 2, 2012
Christine Kottaridi1, Eugenia Bolanaki, Zaharoula Kyriakopoulou
1Department of Biochemistry and Biotechnology, University of Thessaly, 412 21 Larissa, Greece.
Abstract:
Six echovirus strains belonging to serotypes echovirus 6, 13, and 30 were investigated in the present work by sequencing of the whole 2C gene and about 560 nt of the 5' part of 3-dimensional genomic region. Four of the 6 echovirus strains were epidemics, whereas 2 were from sporadic cases. The whole procedure was carried out by using nucleotide distance matrices and phylogeny software. The sequences obtained strengthen the observation that recent echovirus isolates differ significantly from prototype strains in the downstream regions of the genome and provides further evidence that nonstructural enterovirus genes are ubiquitous and may combine freely adapting genomic sequences that are not restricted from the place of isolates' origin. For diagnostic purposes, particular emphasis is given on the utility of sequencing downstream genes and comparison of them with corresponding genomic regions from enteroviral strains that circulated all over the world.
Related Concept Videos
Viral Recombination
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...
Viral Mutations
Exon Recombination
Exon shuffling follows “splice frame rules.” Each exon has three reading...
Gene Conversion
Horizontal Gene Transfer
